|
KMID : 1009020160140020153
|
|
Clinical Psychopharmacology and Neuroscience
2016 Volume.14 No. 2 p.153 ~ p.160
|
|
|
Adjunctive Low-frequency Repetitive Transcranial Magnetic Stimulation over the Right Dorsolateral Prefrontal Cortex in Patients with Treatment-resistant Obsessive-compulsive Disorder: A Randomized Controlled Trial
|
|
Seo Ho-Jun
Jung Young-Eun
Lim Hyun-Kook
Um Yoo-Hyun
Lee Chang-Uk
Chae Jeong-Ho
|
|
|
Abstract
|
|
|
Objective: The present study aimed to evaluate the efficacy of low frequency (LF) repetitive transcranial magnetic stimulation (rTMS) over the right dorsolateral prefrontal cortex (DLPFC) for the treatment of obsessive-compulsive disorder (OCD).
Methods : Twenty-seven patients with treatment resistant OCD were randomly assigned to 3 week either active (n=14) or sham (n=13) rTMS. The active rTMS parameters consisted of 1 Hz, 20-minute trains (1,200 pulses/day) at 100% of the resting motor threshold (MT). OCD symptoms, mood, and anxiety were assessed at baseline and every week throughout the treatment period.
Results : A repeated-measures analysis of variance (ANOVA) was used to evaluate changes on the Yale-Brown Obsessive Compulsive Scale (YBOCS). Our results revealed a significant reduction in YBOCS scores in the active group compared with the sham group after 3 weeks. Similarly, a repeated-measures ANOVA revealed significant effect of time and time×group interaction on scores on the Hamilton Depression Rating Scale and the Clinical Global Impression-Severity scale. There were no reports of any serious adverse effects following the active and sham rTMS treatments.
Conclusion : LF rTMS over the right DLPFC appeared to be superior to sham rTMS for relieving OCD symptoms and depression in patients with treatment-resistant OCD. Further trials with larger sample sizes should be conducted to confirm the present findings.
|
|
|
KEYWORD
|
|
|
Transcranial magnetic stimulation, Obsessive-compulsive disorder, Prefrontal cortex
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
  
|